[bruinsBoxers]

Quote:
Positive Homozygous (2 copies of the mutated gene) We recommend not breeding the homozygous dogs. Dogs that are
homozygous for the mutation appear to have more significant disease and will certainly pass on the mutation.

that is the recommendation by the Veterinary Cardiac Genetics Laboratory

The cardiologist who found and developed the test for the one gene known so far connected to arvc says this .

Positive Heterozygous (1 copy of the mutated gene and 1 copy of a normal gene) Dogs that are positive heterozygous should be carefully evaluated for signs of disease (Holter monitor and possibly an echocardiogram). If an arrhythmia is detected, possible treatment options should be discussed with your veterinarian. Adult dogs that do not show signs of disease and that have other positive attributes could be bred to mutation negative dogs. Puppies may be screened for the mutation and over a few generations, mutation negative puppies may be selected to replace the mutation positive parent and gradually decrease the number of mutation positive dogs in the population.

Positive Homozygous (2 copies of the mutated gene) We recommend not breeding the homozygous dogs unless they are exceptional members of the Boxer community and we need to be sure to maintain their positive attrtibutes in the breed. Dogs that are homozygous for the mutation appear to have more significant disease and will certainly pass on the mutation therefore they should only be bred to a negative dog and over 2 generations of negative crosses a negative puppy could be selected as a replacement.